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Owner David Richardson, 76, said he got the mixed breed dog from an animal home about 26 years ago when she was at least three years old, making Bella's age more than 200 years in canine years.

"There is a considerable increase in the popularity of smaller-breed dogs and a decrease in the popularity of larger-breed dogs," he said.

Hypertrophic osteodystrophy is a bone disease in rapidly growing large breed dogs.

Many large breed dogs appear to be predisposed.

The Westminster Kennel Club was the first member of the pure breed dog registry group, the American Kennel Club.

These findings are important because small- and large-breed dogs are prone to different diseases.